No major schizophrenia locus detected on chromosome 1q in a large multicenter sample.
نویسندگان
چکیده
Reports of substantial evidence for genetic linkage of schizophrenia to chromosome 1q were evaluated by genotyping 16 DNA markers across 107 centimorgans of this chromosome in a multicenter sample of 779 informative schizophrenia pedigrees. No significant evidence was observed for such linkage, nor for heterogeneity in allele sharing among the eight individual samples. Separate analyses of European-origin families, recessive models of inheritance, and families with larger numbers of affected cases also failed to produce significant evidence for linkage. If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small.
منابع مشابه
Is schizophrenia linked to chromosome 1q?
Chromosome 1q? Levinson et al. (1) reported the results of a meta-analysis of families showing no major schizophrenia locus on chromosome 1q. These results, based on a multicenter study of affected sibling pairs (ASPs), are in striking contrast to findings of several recent papers reporting susceptibility loci on 1q in extended families. Significant linkage (LOD 6.5) at 1q21-22 was detected in ...
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ورودعنوان ژورنال:
- Science
دوره 296 5568 شماره
صفحات -
تاریخ انتشار 2002